The FTO gene rs9939609 obesity-risk allele and loss of control over eating
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چکیده
منابع مشابه
The FTO gene rs9939609 obesity-risk allele and loss of control over eating.
BACKGROUND Children with rs9939609 FTO variant alleles (homozygous = AA and heterozygous = AT) are predisposed to greater adiposity than are those with 2 wild-type alleles (TT). OBJECTIVE Because FTO is highly expressed in hypothalamic regions that are important for appetite, FTO genotype may affect energy balance by influencing eating behavior. Loss of control (LOC) eating, a behavior common...
متن کاملFat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa.
OBJECTIVE The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN). METHODS Association of rs993960...
متن کاملObesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis
BACKGROUND Obesity is known to affect cell-mediated immune responses. Recent studies have revealed that genetic polymorphisms in the fat mass and obesity associated (FTO) gene are related to human obesity. We hypothesize that this gene may also play a role in the risk of immune-related infectious diseases such as tuberculosis. METHODS This case-control study included 1625 pulmonary tuberculos...
متن کاملCommon Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females
Numerous studies confirmed the association of FTO (fat mass and obesity associated gene) common variant, rs9939609, with obesity in European populations. However, studies in Asian populations revealed conflicting results. We examined the association of rs9939609 variant of FTO gene with obesity and obesity-related anthropometric and metabolic parameters in Pakistani population. Body weight, hei...
متن کاملThe FTO Gene rs9939609 Polymorphism Predicts Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis
OBJECTIVE Genome-wide association studies have shown that variance in the fat mass- and obesity- associated gene (FTO) is associated with risk of obesity in Europeans and Asians. Since obesity is associated with an increased risk of cardiovascular disease (CVD), several studies have investigated the association between variant in the FTO gene and CVD risk, with inconsistent results. In this stu...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2009
ISSN: 0002-9165,1938-3207
DOI: 10.3945/ajcn.2009.28439